Higuchi connors phase solubility techniques.

Phase solubility techniques @inproceedings{Higuchi1965PhaseST, title={Phase solubility techniques}, author={Takeru. Higuchi and Andrew L. Connors}, year={1965}, url={https://api.semanticscholar.org/CorpusID:100897505} } T. Higuchi, A. Connors; Published 1965; ChemistryPhase solubility studies were conducted following the method reported by Higuchi and Connors . A standard curve of natamycin in methyl alcohol was prepared beforehand. Excess amounts of natamycin were added to 10 mL aqueous solution of ME-β-CD ranging in concentrations from 0 to 10 mM. To achieve equilibrium, the solutions …Phase Solubility Study Figure No. 3. Phase-solubility profiles and classification of complexes. Higuchi and Connors [22] have classified complexes based their effect on substrate solubility as indicated by phase-solubility profiles (Figure 3). A-type phase-solubility profiles are obtained when the solubility of the substrate (i.e., drug ...Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1 H nuclear magnetic resonance (1 H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro …The shake-fl ask method proposed by Higuchi and Connors is the most reliable and widely used solubility measurement method. ... K. A. Connors, Phase-solubility techniques, Adv. Anal. Chem. Instr ...

Solubility phase diagrams were created to evaluate the molar ratios of GAZ/βCD and GAZ/γCD inclusion complexes and their stability in aqueous solution (Fig. 2).The solubility of GAZ increased linearly with the added concentrations of βCD and γCD and produced an A L solubility phase diagram according to the classification by Higuchi, Connors et al. [12] A-type diagrams are formed when the ...Phase Solubility Studies. The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors ().The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. …

(3) (Higuchi and Connors, 1965). As mentioned pre- viously poorly soluble ... Phase-solubility techniques. Adv. Anal. Chem. Instrum. 4, 117–212. Johnson ...All the phase solubility diagrams displayed a typical AL type diagram (i.e. linear increases in luteolin solubility with increasing CD concentrations) within the concentration range studied, indicating a 1:1 stoichiometry of the complexes between luteolin and the five different CDs studied (Higuchi & Connors, 1965). This means that each ...

Feb 5, 2008 · Phase Solubility Studies. The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors . The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. 1. Higuchi T, Connors K A 1965 Phase solubility techniques Advances in Analytical. Chemistry and Instrumentation vol 4(1) pp 117-212. 9. ITM Web of Conferences 45 ...Phase-solubility techniques 来自 scienceopen.com 喜欢 0. 阅读量： 717. 作者： TK Higuchi ， A Connors.Phase solubility study. Phase-solubility study is a traditional and useful approach not only to determine the value of the stability constant, but also to give insight into the stoichiometry of the equilibrium. The practical and phenomenological implications of phase solubility study were developed by Higuchi and Connons (Higuchi & Connors ...The solubilizing potential and complexing tendencies of six cyclodextrins (CyD) with nifedipine in aqueous solution were evaluated using phase solubility methods. Solubility curves of nifedipine with β-CyD, 2-hydroxypropyl-β-CyD (2HP-β-CyD) and 2-hydroxypropyl-γ-cyclodextrin (2HP-γ-CyD) were classified as type AL, while for heptakis (2,6-dimethyl)-β-CyD (DIMEB), randomly methylated-β ...

complexation is the phase so lubili ty method carr ied o ut according to Higuchi and Connors method [14][15] , which examines the e ffec t of nanospo nges on the solubility o f the drug. An

The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors . The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. 1. The apparent solubility of DMA increased ...

The phase solubility diagrams of DMY with α-CD, β-CD, γ-CD, HP-β-CD, and DM-β-CD obtained in water at 25 °C are shown in Fig. 1.The aqueous solubility of DMY increased linearly (r 2 ≥ 0.99) with increasing CD concentration at a range of 0–10 mM. All phase diagrams belonged to A L-type according to Higuchi and Connors, suggesting …Phase solubility test was performed according to the method of Higuchi and Connors . An excess amount of camphor was added to aqueous CD (HPβCD and HPγCD) solutions, and the suspensions were shaken at RT. After equilibrium was achieved at the end of 48 h, the suspensions were filtered with 0.45 μm membrane filter.The equilibrium solubility is based on the phase-solubility technique proposed by Higuchi-Connors. Method Drug dispersed in solvent in a closed container ...Phase Solubility Studies. The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors . The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. 1.The quantification of a natural bioactive compound, pterostilbene (PTT), in commercial capsule dosage form, solubility, and stability samples was carried out using a rapid and sensitive high-performance liquid chromatography (HPLC) approach. PTT was quantified on a Nucleodur (150 mm × 4.6 mm) RP C18 column with a particle size of 5 …

Phase solubility studies were performed by the method previously reported by Higuchi and Connors . Briefly, excess amounts of darifenacin were added to 20 mL of aqueous solutions containing various concentrations of Hp βCD ... T. Higuchi and K. Connors, “Phase solubility techniques,” Advances in Analytical Chemistry and …Phase solubility study. The effect of complexation with βCD and HPβCD on the solubility of GA was assessed. The phase solubility diagram was used in order to evaluate the solubility of GA in the presence of CDs according to Higuchi & Connors . The amount of GA was kept in excess and mixed up with different concentrations of βCD (0–16 mM ...[Article] - Phase Solubility Techniques I'm having a really hard time even finding a link to this article, but everyone cites it: Higuchi, T.; Connors, K. A., 1965. Adv.Phase solubility analysis. The phase solubility diagram for DEN and HPβCD obtained based on the methods of Higuchi and Connors 1965 (Fig. 3) can be categorised as AL-type. The solubility of DEN increases linearly with increase HPβCD concentration. The stability constant K was obtain from the linear portion in the phase …The phase solubility study of CDL with PSC[4]arene and PSC[6]arene were executed according to Higuchi and Connors . Phase solubility studies were accomplished at 27 °C temperature, in triplicate. Excess quantity of CDL (250 mg) was added into different conical flasks containing 150 mL aqueous solutions of PSC[4]arene and PSC[6]arene at …

T. Higuchi and K. A. Connors. Phase solubility techniques. Adv. Anal. Chem. Instrum. 4:117–212 (1965). ... In S. Yalkowsky (ed.), Techniques of Solubilization of Drugs, Marcel Dekker, New York, 1981, pp. 135–149. Google Scholar T. Higuchi and H. Kristiansen. Binding specificity between small organic solutes in aqueous solution ...Phase Solubility Study. Phase solubility study was carried out according to the Higuchi and Connors method . For phase solubility study of a binary system, an excess amount of PLDN was added to aqueous solutions containing increasing concentrations of β-CD (3–15 mM). The solutions were kept on rotary shaker for 48 h at 25 °C.

The shake-fl ask method proposed by Higuchi and Connors is the most reliable and widely used solubility measurement method. ... K. A. Connors, Phase-solubility techniques, Adv. Anal. Chem. Instr ...Solubility studies. The phase-solubility diagram corresponding to DPS:βCD system is illustrated in Fig. 5. It was performed according to the method reported by of Higuchi and Connors in order to determine the stability constant of the suggested complex and evaluate its stoichiometry. Measurements were made at 291 nm, which corresponds to the ...Higuchi T, Connors K. Phase-solubility techniques. Adv Anal Chem Instrum. 1965;7:117–212. Google Scholar Jouyban A. Handbook of solubility data for pharmaceuticals. Boca Raton: CRC Press; 2009. United States Pharmacopeial Convention. USP 38–NF 33, General notices and requirements.Abstract. Solubility is one of the most important physicochemical properties studied during pharmaceutical preformulation. For liquid dosage form development, accurate solubility …Using the approach of Higuchi and Connors, phase-solubility studies were performed at increasing concentrations of the three CD. Fig. 2 shows that the solubility of CBD increased linearly with the concentrations of HPβCD and HPγCD which corresponds to the AL type profile (formation of 1:1 inclusion complexes). On the contrary, the phase ...... Higuchi-Connors phase solubility method. この論文は、ヒグチコンノル相溶解法 ... techniques including Fourier Transform Infrared Spectroscopy (FTIR) and ...

Abstract. The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance ...

Characterization of ternary complexes of meloxicam-HPβCD and PVP or L-arginine prepared by the spray-drying techniqueTernary complexes of meloxicam (ME) (a poorly water soluble anti-inflammatory drug) with hydroxypropyl-β-cyclodextrin (HPβCD) and either a hydrophilic polymer, namely, polyvinyl pyrrolidone (PVP) or a basic amino acid …

2.3. Solubility Measurements. Phase-solubility studies of benzoyl metronidazole in aqueous solutions of β-CD were carried out according to the Higuchi-Connors procedure . Various amounts of β-CD were generally dissolved in distilled water, and excess amounts of benzoyl metronidazole were loaded in glass vials. The vials were …Solubility studies. The phase-solubility diagrams were made according to the Higuchi and Connors method (Higuchi and Connors, 1969). For this purpose, aqueous solutions of HPβCD with concentrations of 0–2.6 mM with a known concentration of Los at 30 mM were prepared. These were placed in a thermostatic bath at 298 K by 48 h.Types of phase-solubility diagrams according to Higuchi and Connors showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are formed when the drug/CD complex is soluble in the aqueous complexation media and they are usually associated with the water-soluble CD derivatives.In this regard, the well-known solubility diagram design (T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212) should be done in order to obtain information about the drug solubility in presence of increasing CD concentrations.2.3 Phase solubility studies. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). 21 Excess amounts of EO were added to CD solutions at different concentrations ranging from 0 to 40mM. The mixtures were shaken overnight at 25°C and then filtered through a 0.45 μm membrane filter.T. Higuchi and K. A. Connors. Phase solubility techniques. Adv. Anal. Chem. Instrum. 4:117-212 (1965). ... In S. Yalkowsky (ed.), Techniques of Solubilization of Drugs, Marcel Dekker, New York, 1981, pp. 135-149. Google Scholar T. Higuchi and H. Kristiansen. Binding specificity between small organic solutes in aqueous solution ...Shake flask method was employed for the aqueous solubility measurements, performed in triplicates by Higuchi and Connors method . An excess amount of cocrystals were added to the flask containing distilled water. The solutions were vortexed for 2 min and placed on a rotary shaker at 100 rpm and 27±0.5° for 24 h. ... Higuchi TK, Connors A. …Phase solubility measurements of SBE 7-β-CD and valsartan were performed using the Higuchi-Connors technique . In separate conical flasks holding 10 ml of distilled water having increasing concentrations of SBE 7 -β-CD starting from 0.5 to 5 mM, an excess of valsartan was added.2.3. Solubility Measurements. Phase-solubility studies of benzoyl metronidazole in aqueous solutions of β-CD were carried out according to the Higuchi-Connors procedure . Various amounts of β-CD were generally dissolved in distilled water, and excess amounts of benzoyl metronidazole were loaded in glass vials. The vials were …

Phase solubility studies. Solubility measurements were performed in triplicate using the method reported by Higuchi and Connors (Higuchi et al., 1965). An excess amount of ALLO was added to the aqueous solutions of each carrier containing increasing concentrations of the individual carrier (i.e., 0, 1, 5, and 10 % w/v).Solubility studies. The phase-solubility diagrams were made according to the Higuchi and Connors method (Higuchi and Connors, 1969). For this purpose, aqueous solutions of HPβCD with concentrations of 0–2.6 mM with a known concentration of Los at 30 mM were prepared. These were placed in a thermostatic bath at 298 K by 48 h.The solubilities of voriconazole, ketoconazole, and clotrimazole with and without hydroxybutenyl-β-cyclodextrin (HBenBCD) in aqueous media were examined. The solubility of these antifungal drugs was significantly improved by complexation with HBenBCD. Both the pH and the type of buffer used to adjust the medium pH had a very significant effect on drug solubilities and the apparent binding ...The Higuchi–Connors phase-solubility method8) is very often used to ... The phase-distribution method is a very versatile and fast method and has the advantage, ...Instagram:https://instagram. ava black basketball8 00 am pacific standard timemasters requirementscorrido mexicano Phase-solubility analysis. Phase-solubility study was carried out according to the method of Higuchi and Connors . Excess amount of repaglinide (approx. 10 mg) was added to 2.5 mL 10 mM phosphate buffer (pH 6 and pH 3.5) containing increasing amounts of Captisol ® (10 −3 –10 −1 M) and shaken at 25 ± 0.5 °C.Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, … what rock is shalecici g T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo Studies Phase solubility study. Classification of inclusion complex formation and stability of the inclusion compounds were evaluated by phase solubility study (Higuchi & Connors, 1965). An excess of black pepper oil was added to 10 mL aqueous solutions of HPβCD ranging in concentration from 0 to 10 mmol/L and incubated at 25 and 35 °C for 24 h with ... what time is orientation The phase solubility diagrams for curcumin/cyclodextrin polymer inclusion complex is shown in Figure 5, which displayed an AL-type according to Higuchi and Connors . According to Higuchi and Connors’ theory, the 1:1 stoichiometry of the inclusion complex was achieved from the initial ascending part of the curve, a nearly …Fig. 1 shows the phase solubility diagrams of sulfamethizole with the cyclodextrins used, BCD and HPBCD, at 37°C. The solubility of the drug increased linearly as a function of the CD concentration, a feature of the A L-type complex, showing that water-soluble complexes exit in solution.