Phenylephrine reddit.

TIL that Phenylephrine, the nasal decongestant that replaced pseudoephedrine in OTC cold medicine, was shown to be ineffective vs placebo at up to 4X the recommended dose, and was not well tolerated starting at 4X the recommended dose. : r/todayilearned by teefourPhenylephrine is a type of nasal decongestant in over-the-counter (OTC) medications, such as Sudafed PE. Phenylephrine is available as a standalone …Takeaway. Pseudoephedrine and phenylephrine are both nasal decongestants but can have different side effects. You can only purchase pseudoephedrine from pharmacy staff and have to show your ID ...Jan 30, 2011 · Doc Hydramine. The Sudafed PE and all the other Phenylepherine cold remedies are garbage. It was probably pushed through the approval process because they were desperate for a decongestant that you couldn't make meth from. So, they approved something that was not very effective, since there weren't any other options. 4 oct. 2023 ... ... Reddit Print Story Like. An advisory panel to the Food and Drug ... phenylephrine doesn't work to clear nasal congestion when taken orally.

The FDA-approved indication for intravenous (IV) phenylephrine hydrochloride is for increasing blood pressure in adults with clinically significant hypotension resulting primarily from vasodilation in such settings as septic shock or anesthesia. Phenylephrine HCL is also used over-the-counter in ophthalmic formulations to promote …

Other pharmacists have expressed concerns over phenylephrine's effectiveness as a nasal decongestant,[1] and other clinicians have indicated concern for regulatory actions that reduced the availability of pseudoephedrine.[12][13] A subsequent meta-analysis by the same researchers concluded that there is insufficient evidence for its ...

2 great_site_not • 5 yr. ago You need different friends. 200mg of phenylephrine is extremely dangerous, and anyone who'd hand it to you and tell you it's fine is dangerously negligent (assuming it wasn't malicious).subscribers. 426 votes, 171 comments. 149K subscribers in the pharmacy community. A subreddit for pharmacists, pharmacy students, techs, and anyone else in the….Wait until it's completely out of your system. If it's a 4-6 hour dose, wait the full 6 at least. If it's 12, wait at least 12, etc. Most cold meds and decongestants are downers, meaning they slow everything down, making you sleepy.Sudafed is a stimulant As a stimulant medication, Sudafed can mask that tipsy feeling that sometimes occurs after a drink or two. And masking inebriation is a great way to wind up hungover (on a side note, if you do find yourself hungover for this reason or some other, here are a few things you can do to alleviate symptoms). “Sudafed can …

Fischman: Today, we’re talking about decongestants. Scientists who advise the FDA recently concluded that phenylephrine, a common decongestant in cold …

Take a syringe and draw up 1 ml of phenylephrine from the vial (vial concentration must be 10 mg/ml) Inject this into a 100 ml bag of NS. Now you have 100 mls of phenylephrine 100 mcg/ml. Draw up some into a syringe; each ml in the syringe is 100 mcg. Dose: 0.5-2 ml every 1-5 minutes (50-200 mcg) No extravasation worries! Mixing …

Phenylephrine is a direct-acting sympathomimetic amine that functions as an alpha-1 adrenergic agonist. Its chemical structure is related to epinephrine and ephedrine and possesses potent vasoconstriction properties when given intravenously or applied directly to mucosal membranes.18 jan. 2019 ... Share on Reddit. Email Copy site URL to your clipboard. Cold ... Decongestants – like pseudoephedrine or phenylephrine – constrict blood vessels.Agreed. Currently I am in pharmacy school. All the literature points to that it is either ineffective or the dosing is not right. Regardless, replacing pseduoephedrine with phenylephrine has not curbed methamphetamine production. False product extentions are confusing patients.DEAR MAYO CLINIC: I have used decongestants over the years when I'm ill, but my doctor recently said that I should be cautious because nonprescription decongestants can have significant side effects. Is this true? ANSWER: While many people rely on nasal decongestants to help ease nasal symptoms of a cold or flu, these medications can sometimes cause […]31 août 2023 ... Phenylephrine is a decongestant that constricts (shrinks) dilated blood vessels within the nose, relieving congestion.Research comparing phenylephrine to a placebo in the treatment of nasal congestion has yielded mixed results, with some studies showing minimal effectiveness compared to a placebo. This lack of significant difference in symptom relief has raised questions about the efficacy of phenylephrine in some cases.

The FDA says the oral form of phenylephrine, a common decongestant ingredient used in cold and allergy drugs like Sudafed, is ineffective. The nasal spray form of phenylephrine can still provide temporary relief from congestion, but overuse can cause rebound congestion. The best remedies for congestion caused by cold and flu are rest …The only way to know for sure is to try something that is just pseudoephedrine and see if you get the same response. Pseudoephedrine basically floods your brain with norepinephrine. I've read that Strattera functions similarly by improving your brain's ability to update norepinephrine. I would definitely recommend that you see an ADHD ...Fischman: Today, we’re talking about decongestants. Scientists who advise the FDA recently concluded that phenylephrine, a common decongestant in cold medicines, doesn’t work. We’ll talk ...Phenylephrine is a medication used as a decongestant for uncomplicated nasal congestion, used to dilate the pupil, used to increase blood pressure (given intravenously in cases of hypotension), and used to relieve hemorrhoids. It is a selective α 1-adrenergic receptor agonist with minimal to no beta-adrenergic activity. It causes constriction of both arteries and veins.Phenylephrine is a decongestant and works by constricting blood vessels (although it’s not very good at this). I can’t imagine it exacerbating RLS because it doesn’t enter the CNS at all and it’s also just kind of a useless systemic drug in general. That doesn’t mean it couldn’t make your RLS worse by acting locally on the blood ...

Ephedrine hits all adrenergic, with a slight preference for beta (breathing, HR, and some weight loss). Pseudoephedrine or phenylephrine we'll come in and bind mostly alpha, which won't do crap except raise BP. If you're in WA then just drive to Canada and buy it from a supplement store if you're close enough.

4 comments [deleted] • 5 yr. ago Phenylephrine works as a vasoconstrictor, which raises BP and heart rate. Probably why its associated with an increased risk of …Apr 11, 2023 · Regarding its effectiveness as a treatment for nasal congestion, the answer is no. In fact, some research has found that at the current recommended doses of phenylephrine it offers minimal symptom improvement. It may be safer for people with high blood pressure and heart disease, but there is not enough research to be certain. According to Wikipedia: "Methcathinone production utilizes the oxidation of pseudoephedrine or ephedrine, the former being preferred because of much higher yields achieved. Oxidation of pseudoephedrine to methcathinone requires little chemistry experience, making it (relatively) easy to synthesize. [5] [unreliable source?]Evidence of phenylephrine's effectiveness comes from a review that combined and analyzed the results of seven individual studies. It found the drug had a small but real effect on nasal airway ...so i have a bunch of phenylephrine hydrochloride from pills they only contain 500mg of panadol and 5mg of phenylephrine hydrochloride each and there's 20 tablets per box if 3 friends got 3 boxes and we extracted the phenylephrine hydrochloride we'd have around 300mg give or take because we're using a sketchy homemade chemistry setup rather …Technically you could convert a steak into methamphetamine, or any other drug, that's the beauty of chemistry. Yeah, I knew it was a long shot. They didn't replace psuedo with PE for nothing. It would just be awesome to beat them at their own game! make amphetamine from benzaldehyde is way easier.4 oct. 2023 ... ... Reddit Print Story Like. An advisory panel to the Food and Drug ... phenylephrine doesn't work to clear nasal congestion when taken orally.Though we first petitioned the F.D.A. to look into phenylephrine more than 15 years ago, it wasn’t until company-funded studies from Schering-Plough, later …DEAR MAYO CLINIC: I have used decongestants over the years when I'm ill, but my doctor recently said that I should be cautious because nonprescription decongestants can have significant side effects. Is this true? ANSWER: While many people rely on nasal decongestants to help ease nasal symptoms of a cold or flu, these medications can sometimes cause […]

Significantly more effective as a decongestant than phenylephrine. May be used in addition to pain relievers, antihistamines, cough suppressants, expectorants, or antibiotics. Some manufacturers have reformulated cough and cold preparations to contain phenylephrine rather than pseudoephedrine. Extended-release tablets may be administered once ...

A warning about stimulants and cold medicine. In a nutshell, I was on 10 of Prozac titrating up to 20 slowly, and had just increased my dose of Vyvanse again when my asthma flaired up. I had to take my Albuterol inhaler and Robitussin with dextromethorphan and guaifenesin. I had a nightmare response that caused a crazy panic episode that lasted ...

Phenylephrine is a type of nasal decongestant in over-the-counter (OTC) medications, such as Sudafed PE. Phenylephrine is available as a standalone medication, or as part of a multidrug ...Aug 17, 2023 · The most important difference between phenylephrine (PE) and pseudoephedrine (PDE) is that the efficacy as PE as a decongestant is unproven, whereas there is some evidence that oral PDE is effective. The main reasons for a lack of effectiveness of PE include: Although both PE and PDE are well absorbed from the gut, PE is extensively metabolized ... Reddit; Print; By Tina Hesman Saey. April 30, 2020 at 5:36 pm. Scientists are investigating a variety of drugs, including ones for anxiety and allergies, that might prevent the coronavirus from ...The best non-prescription, safe, legal ADHD "mitigatior" that I have found is xenon. It greatly helps with meditation, is anti-anxiety, and apparently helps with exercise as well. It will not "cure" ADHD -- that is a very complex issue. It is more expensive than most nootropic pills -- but google around and find something you can affore.Sudafed is a stimulant As a stimulant medication, Sudafed can mask that tipsy feeling that sometimes occurs after a drink or two. And masking inebriation is a great way to wind up hungover (on a side note, if you do find yourself hungover for this reason or some other, here are a few things you can do to alleviate symptoms). “Sudafed can …Like super fast heart rate, shaky, sweaty,anxiety, kinda dizzy. Feels like I did a fat line of bad coke. I am not a rookie or a light weight and I take actual stimulants often. I just had no idea a decongestant could make me feel like this. Is that normal? Phenylephrine may cause serious side effects. Stop using phenylephrine and call your doctor at once if you have: fast, pounding, or irregular heartbeat; severe dizziness or nervousness; sleep problems ( insomnia ); or. increased blood pressure--severe headache, blurred vision, pounding in your neck or ears.Push-dose vasopressors, or push-dose pressors, refers to administration of intermittent, small doses of vasopressors to optimize a patient’s hemodynamic status [2, 3]. Commonly used push-dose vasopressors include epinephrine and phenylephrine [2, 3]. Push-dose administration is a long standing practice amongst anesthesiologists to …Phenylephrine comes as a 0.125%, 0.25%, 0.5%, and 1% solution (liquid) to spray into the nose. It is usually used as needed, not more than every 4 hours. The 0.5% and 1% solutions may be used in adults and children 12 years of age and older. The 0.25% solution may be used in children 6 to 12 years of age.

Phenylephrine is a direct-acting sympathomimetic amine chemically related to adrenaline and ephedrine with potent vasoconstrictor property. Phenylephrine is a post-synaptic alpha-adrenergic receptor agonist that causes vasoconstriction, increases systolic/diastolic pressures, reflex bradycardia, and stroke output. Reply.The only way to know for sure is to try something that is just pseudoephedrine and see if you get the same response. Pseudoephedrine basically floods your brain with norepinephrine. I've read that Strattera functions similarly by improving your brain's ability to update norepinephrine. I would definitely recommend that you see an ADHD ...Phenylephrine comes as a 0.125%, 0.25%, 0.5%, and 1% solution (liquid) to spray into the nose. It is usually used as needed, not more than every 4 hours. The 0.5% and 1% solutions may be used in adults and children 12 years of age and older. The 0.25% solution may be used in children 6 to 12 years of age.Phenylephrine was approved by the FDA for over-the-counter use in the 1970s, but it became even more common after 2005, when legislation restricted access to OTC drugs that use a similar ...Instagram:https://instagram. mesa az 10 day weatherwkyt weather radar lexington kypacific time to cdtwakanda forever 1234 movies Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Phenylephrine is a decongestant. Ibuprofen and phenylephrine is a combination medicine used to ...The phenylephrine (PE) form is no better than a placebo when taken in pill form. It only works as a decongestant when used in a liquid form on direct contact with nasal tissues. I still can't believe they actually approved the PE forms of decongestant pills. is car shield legitimatewestamerica bank routing number Super interesting article thanks! Epipens stored in EMS vehicles between 1-11 years past expiration only contained up to 31% of original potency. While epipens tested with normal storage up to 90 months past expiration date decreased proportionally with age. Makes me much more careful with epipens -- that's for damn sure! online retail naics code It really just depends for everyone if it will give you bad side effects or not. Since you have a low tolerance to adderall, take 5mg first and see how bad the load is. If it isn't too bad, you can take more, but know that the half life of phenylephrine is about 3 hours, so it does not go away quickly. willis81808 • 9 yr. ago.That much phenylephrine 10% could have really messed with your cardiovascular system. Someone please fill me in if there's a diagnostic or therapeutic justification for the amount of drops OP received.Sep 14, 2023 · Phenylephrine — the ingredient deemed ineffective — took off in popularity as a replacement for pseudoephedrine. Mike Koelzer, a pharmacist in Grand Rapids, Michigan, said he doesn’t expect any...